Ctr for Pharmaceutical Biotech

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Ribosomes Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
Peptides Medicine & Life Sciences
Peptidyl Transferases Medicine & Life Sciences
Macrolides Medicine & Life Sciences
Linezolid Medicine & Life Sciences
Halobacterium salinarum Medicine & Life Sciences
Mutation Medicine & Life Sciences

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Projects 1977 2020

Context-specific action of antibiotics targeting the catalytic center of the bacterial ribosome

Mankin, A.


Project: Research projectResearch Project

Development of Novel S. aureus Antibiotics with Reduced Resistance Susceptibility

Johnson, M. E. & Mehboob, S.


Project: Research projectSmall Business Technology Transfer (STTR) Grants - Phase I

Development of broad spectrum Hepatitis C Virus NS3/4A protease inhibitors

Johnson, M. E. & Hyun, L.


Project: Research projectSmall Business Technology Transfer (STTR) Grants - Phase I

Research Output 1974 2016

6 Citations
Molecular Dynamics
Molecular dynamics
3 Citations

Identification of B. anthracis N5-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via fragment library screening

Lei, H., Jones, C., Zhu, T., Patel, K., Wolf, N. M., Fung, L. W., Lee, H. & Johnson, M. E., Feb 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 4, p. 596-605 10 p.

Research output: Contribution to journalArticle

Intramolecular Transferases
Bacillus anthracis
Catalytic Domain
21 Citations

Nascent peptide assists the ribosome in recognizing chemically distinct small molecules

Gupta, P., Liu, B., Klepacki, D., Gupta, V., Schulten, K., Mankin, A. S. & Vázquez-Laslop, N., Feb 1 2016, In : Nature Chemical Biology. 12, 3, p. 153-158 6 p.

Research output: Contribution to journalArticle