Institute for Tuberculosis Research

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Mycobacterium tuberculosis Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
In Vitro Techniques Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
Nuclear magnetic resonance Chemical Compounds
Tuberculosis Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Derivatives Chemical Compounds

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Projects 1988 2015

In vitro detection of anti-TB liver metabolites in early drug discovery

Franzblau, S. G.

National Institutes of Health

2/15/121/31/15

Project: Research projectExploratory/Developmental Grants

Metabolites
Liver
Drug Discovery
Assays
Enzymes

Novel Indigoid Anti-Tuberculosis Agents

Klein, L.

2/15/128/31/14

Project: Research projectExploratory/Developmental Grants

Lead identification of 1,4-benzoxazines as anti-tuberculosis agents

Franzblau, S. G.

National Institutes of Health

9/20/068/31/09

Project: Research projectExploratory/Developmental Grants

Benzoxazines
Tuberculosis
Lead
Pharmaceutical Preparations
Macrophages

Research Output 1968 2018

Protein moonlighting: What is it, and why is it important?

Jeffery, C. J. Jan 19 2018 In : Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1738, 20160523

Research output: Research - peer-reviewReview article

heat shock proteins
catalytic activity
biochemistry
proteomics
physiology

2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE)

Bhattacharjee, A., Sinha, A., Ratia, K., Yin, L., Delgado-Rivera, L., Petukhov, P. A., Thatcher, G. R. J. & Wardrop, D. J. Dec 14 2017 In : ACS Medicinal Chemistry Letters. 8, 12, p. 1241-1245 5 p.

Research output: Research - peer-reviewArticle

Cystathionine gamma-Lyase
Cystathionine beta-Synthase
Hydrogen Sulfide
Gasotransmitters
Physiological Phenomena
1 Citations

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

Tong, A. S. T., Choi, P. J., Blaser, A., Sutherland, H. S., Tsang, S. K. Y., Guillemont, J., Motte, M., Cooper, C. B., Andries, K., Van Den Broeck, W., Franzblau, S. G., Upton, A. M., Denny, W. A., Palmer, B. D. & Conole, D. Oct 12 2017 In : ACS Medicinal Chemistry Letters. 8, 10, p. 1019-1024 6 p.

Research output: Research - peer-reviewArticle

bedaquiline
Diarylquinolines
Tuberculosis
Pharmaceutical Preparations
Half-Life