Institute for Tuberculosis Research

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Mycobacterium tuberculosis Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
In Vitro Techniques Medicine & Life Sciences
Nuclear magnetic resonance Chemical Compounds
Tuberculosis Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
Derivatives Chemical Compounds

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Projects 1988 2015

Novel Indigoid Anti-Tuberculosis Agents

Klein, L.

2/15/128/31/14

Project: Research projectExploratory/Developmental Grants

In vitro detection of anti-TB liver metabolites in early drug discovery

Franzblau, S. G.

National Institutes of Health

2/15/121/31/15

Project: Research projectExploratory/Developmental Grants

Metabolites
Liver
Drug Discovery
Assays
Enzymes

Lead identification of 1,4-benzoxazines as anti-tuberculosis agents

Franzblau, S. G.

National Institutes of Health

9/20/068/31/09

Project: Research projectExploratory/Developmental Grants

Benzoxazines
Tuberculosis
Lead
Pharmaceutical Preparations
Macrophages

Research Output 1968 2017

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

Tong, A. S. T., Choi, P. J., Blaser, A., Sutherland, H. S., Tsang, S. K. Y., Guillemont, J., Motte, M., Cooper, C. B., Andries, K., Van Den Broeck, W., Franzblau, S. G., Upton, A. M., Denny, W. A., Palmer, B. D. & Conole, D. Oct 12 2017 In : ACS Medicinal Chemistry Letters. 8, 10, p. 1019-1024 6 p.

Research output: Research - peer-reviewArticle

bedaquiline
Diarylquinolines
Tuberculosis
Pharmaceutical Preparations
Half-Life
1 Citations

6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases

Thompson, A. M., Blaser, A., Palmer, B. D., Anderson, R. F., Shinde, S. S., Launay, D., Chatelain, E., Maes, L., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z. & Denny, W. A. Jun 1 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 11

Research output: Research - peer-reviewArticle

Neglected Diseases
Thiazoles
Tuberculosis
Oxazoles
2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine
1 Citations

7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis

Thompson, A. M., O’Connor, P. D., Marshall, A. J., Yardley, V., Maes, L., Gupta, S., Launay, D., Braillard, S., Chatelain, E., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Cooper, C. B. & Denny, W. A. May 25 2017 In : Journal of Medicinal Chemistry. 60, 10, p. 4212-4233 22 p.

Research output: Research - peer-reviewArticle

Antitubercular Agents
Visceral Leishmaniasis
oxazine 1
Solubility
Safety