• 4453 Citations
  • 35 h-Index
1979 …2019
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  • 1 Similar Profiles
Hepatitis B virus Medicine & Life Sciences
Nucleocapsid Medicine & Life Sciences
Virus Replication Medicine & Life Sciences
Hepatitis B Surface Antigens Medicine & Life Sciences
Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Hepatocyte Nuclear Factors Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
hepatocytes Agriculture & Biology

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Projects 1983 2016

Epigenetic regulation of HBV transcription and replication by FoxA/HNF3

McLachlan, A.


Project: Research projectExploratory/Developmental Grants

Discovery of novel anti-HBV compounds targeting host factors

Petukhov, P. A. & McLachlan, A.

National Institutes of Health


Project: Research projectExploratory/Developmental Grants

Hepatitis B virus
Drug Design
Virus Diseases
Virus Replication


McLachlan, A.


Project: Research project

Research Output 1979 2019

  • 4453 Citations
  • 35 h-Index
  • 81 Article

Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis

Shalaby, R. E., Iram, S., Oropeza, C. E. & McLachlan, A., Jan 2 2019, In : Virology. 526, p. 214-221 8 p.

Research output: Contribution to journalArticle

Hepatitis Viruses
PPAR gamma
Hepatocellular Carcinoma
Virus Replication
2 Citations

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation

McFadden, V. C., Shalaby, R. E., Iram, S., Oropeza, C. E., Landolfi, J., Lyubimov, A. V., Maienschein-Cline, M., Green, S., Kaestner, K. H. & McLachlan, A., Feb 1 2017, In : PLoS Pathogens. 13, 2, e1006239.

Research output: Contribution to journalArticle

Viral DNA
DNA Methylation
Hepatitis B virus
Transcription Factors

PGC1α transcriptional adaptor function governs hepatitis B virus replication by controlling HBcAg/p21 protein-mediated capsid formation

Shalaby, R. E., Iram, S., Çakal, B., Oropeza, C. E. & McLachlan, A., Oct 1 2017, In : Journal of Virology. 91, 20, e00790-17.

Research output: Contribution to journalArticle

Hepatitis B Core Antigens
Hepatitis B virus
Capsid Proteins
Virus Replication
11 Citations

Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice

Koh, K. H. Y., Pan, X., Zhang, W., McLachlan, A., Urrutia, R. & Jeong, H-Y., Dec 1 2014, In : Molecular Pharmacology. 86, 6, p. 727-735 9 p.

Research output: Contribution to journalArticle

Kruppel-Like Transcription Factors
Cytochrome P-450 CYP2D6
Transcriptional Activation
181 Citations

Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection

Wooddell, C. I., Rozema, D. B., Hossbach, M., John, M., Hamilton, H. L., Chu, Q., Hegge, J. O., Klein, J. J., Wakefield, D. H., Oropeza, C. E., Deckert, J., Roehl, I., Jahn-Hofmann, K., Hadwiger, P., Vornlocher, H. P., McLachlan, A. & Lewis, D. L., May 1 2013, In : Molecular Therapy. 21, 5, p. 973-985 13 p.

Research output: Contribution to journalArticle

Chronic Hepatitis B
Virus Diseases
RNA Interference