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  • 29 Similar Profiles
Mycobacterium tuberculosis Medicine & Life Sciences
Tuberculosis Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
In Vitro Techniques Medicine & Life Sciences
Derivatives Chemical Compounds
Assays Chemical Compounds
Nuclear magnetic resonance Chemical Compounds
Growth Medicine & Life Sciences

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Projects 1988 2015

In vitro detection of anti-TB liver metabolites in early drug discovery

Franzblau, S. G.

National Institutes of Health

2/15/121/31/15

Project: Research projectExploratory/Developmental Grants

Metabolites
Liver
Drug Discovery
Assays
Enzymes

Lead identification of 1,4-benzoxazines as anti-tuberculosis agents

Franzblau, S. G.

National Institutes of Health

9/20/068/31/09

Project: Research projectExploratory/Developmental Grants

Benzoxazines
Tuberculosis
Lead
Pharmaceutical Preparations
Macrophages
Mycobacterium leprae
Maintenance
Growth
Palmitates
Pharmaceutical Preparations

Research Output 1983 2017

  • 10594 Citations
  • 50 h-Index
  • 337 Article
  • 1 Chapter

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

Tong, A. S. T., Choi, P. J., Blaser, A., Sutherland, H. S., Tsang, S. K. Y., Guillemont, J., Motte, M., Cooper, C. B., Andries, K., Van Den Broeck, W., Franzblau, S. G., Upton, A. M., Denny, W. A., Palmer, B. D. & Conole, D. Oct 12 2017 In : ACS Medicinal Chemistry Letters. 8, 10, p. 1019-1024 6 p.

Research output: Research - peer-reviewArticle

bedaquiline
Diarylquinolines
Tuberculosis
Pharmaceutical Preparations
Half-Life
1 Citations

6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases

Thompson, A. M., Blaser, A., Palmer, B. D., Anderson, R. F., Shinde, S. S., Launay, D., Chatelain, E., Maes, L., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z. & Denny, W. A. Jun 1 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 11

Research output: Research - peer-reviewArticle

Neglected Diseases
Thiazoles
Tuberculosis
Oxazoles
2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine
1 Citations

7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis

Thompson, A. M., O’Connor, P. D., Marshall, A. J., Yardley, V., Maes, L., Gupta, S., Launay, D., Braillard, S., Chatelain, E., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Cooper, C. B. & Denny, W. A. May 25 2017 In : Journal of Medicinal Chemistry. 60, 10, p. 4212-4233 22 p.

Research output: Research - peer-reviewArticle

Antitubercular Agents
Visceral Leishmaniasis
oxazine 1
Solubility
Safety

Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea

Velappan, A. B., Charan Raja, M. R., Datta, D., Tsai, Y. T., Halloum, I., Wan, B., Kremer, L., Gramajo, H., Franzblau, S. G., Kar Mahapatra, S. & Debnath, J. 2017 In : European Journal of Medicinal Chemistry. 125, p. 825-841 17 p.

Research output: Research - peer-reviewArticle

Mycolic Acids
Mycobacterium
Urea
Macrophages
Molecules
1 Citations

Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant: Mycobacterium tuberculosis

Lu, X., Hu, X., Liu, Z., Zhang, T., Wang, R., Wan, B., Franzblau, S. G. & You, Q. 2017 In : MedChemComm. 8, 6, p. 1303-1306 4 p.

Research output: Research - peer-reviewArticle

Hydrazones
Mycobacterium tuberculosis
Amides
Pharmaceutical Preparations
Extensively Drug-Resistant Tuberculosis