• 11518 Citations
  • 52 h-Index
1983 …2018
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  • 26 Similar Profiles
Mycobacterium tuberculosis Medicine & Life Sciences
Tuberculosis Medicine & Life Sciences
Mycobacterium leprae Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Antitubercular Agents Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Assays Chemical Compounds
Derivatives Chemical Compounds

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Projects 1988 2015

In vitro detection of anti-TB liver metabolites in early drug discovery

Franzblau, S. G.

National Institutes of Health

2/15/121/31/15

Project: Research projectExploratory/Developmental Grants

Metabolites
Liver
Assays
Drug Discovery
Prodrugs

Lead identification of 1,4-benzoxazines as anti-tuberculosis agents

Franzblau, S. G.

National Institutes of Health

9/20/068/31/09

Project: Research projectExploratory/Developmental Grants

Benzoxazines
Tuberculosis
Macrophages
Pharmaceutical Preparations
Cell Line
Mycobacterium leprae
Palmitates
Maintenance
Growth
Pharmaceutical Preparations

Research Output 1983 2018

  • 11518 Citations
  • 52 h-Index
  • 349 Article
  • 1 Chapter

Anti-mycobacterium tuberculosis activity of esters of quinoxaline 1,4-Di-N-oxide

Palos, I., Luna-Herrera, J., Lara-Ramírez, E. E., Loera-Piedra, A., Fernández-Ramírez, E., Guadalupe Aguilera-Arreola, M., Paz-González, A. D., Monge, A., Wan, B., Franzblau, S. & Rivera, G. Jan 1 2018 In : Molecules. 23, 6, 1453

Research output: Contribution to journalArticle

Tamper resistant packaging
Slip forming
tuberculosis
quinoxalines
Quinoxalines

Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H -imidazo[2,1- b] [1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis

Thompson, A. M., O'Connor, P. D., Marshall, A. J., Blaser, A., Yardley, V., Maes, L., Gupta, S., Launay, D., Braillard, S., Chatelain, E., Wan, B., Franzblau, S. G., Ma, Z., Cooper, C. B. & Denny, W. A. Mar 22 2018 In : Journal of Medicinal Chemistry. 61, 6, p. 2329-2352 24 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Cricetinae
Solubility
Oxazepines
Oxazoles
1 Citations

Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin

Choules, M. P., Klein, L. L., Lankin, D. C., McAlpine, J. B., Cho, S. H., Cheng, J., Lee, H., Suh, J. W., Jaki, B. U., Franzblau, S. G. & Pauli, G. F. Jun 15 2018 In : Journal of Organic Chemistry. 83, 12, p. 6664-6672 9 p.

Research output: Contribution to journalArticle

Slip forming
Linguistics
1 Citations

Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity

Harbut, M. B., Yang, B., Liu, R., Yano, T., Vilchèze, C., Cheng, B., Lockner, J., Guo, H., Yu, C., Franzblau, S. G., Petrassi, H. M., Jacobs, W. R., Rubin, H., Chatterjee, A. K. & Wang, F. Mar 19 2018 In : Angewandte Chemie - International Edition. 57, 13, p. 3478-3482 5 p.

Research output: Contribution to journalArticle

Slip forming
Lattice vibrations
Adenosinetriphosphate
Molecules
Scaffolds
1 Citations

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Blaser, A., Franzblau, S. G., Cooper, C. B., Upton, A. M., Lotlikar, M. U., Denny, W. A. & Palmer, B. D. Jan 1 2018 (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

bedaquiline
Structure-Activity Relationship
Tuberculosis
Potassium Channels
Pharmaceutical Preparations