Anisotropic composite material phantom to improve skeletal muscle characterization using magnetic resonance elastography

Martina Guidetti, Gloria Lorgna, Dieter Klatt, Pasquale Vena, Thomas J. Royston

Research output: Contribution to journalArticle

Abstract

The presence and progression of neuromuscular pathology, including spasticity, Duchenne's muscular dystrophy and hyperthyroidism, has been correlated with changes in the intrinsic mechanical properties of skeletal muscle tissue. Tools for noninvasively measuring and monitoring these properties, such as Magnetic Resonance Elastography (MRE), could benefit basic research into understanding neuromuscular pathologies, as well as translational research to develop therapies, by providing a means of assessing and tracking their efficacy. Dynamic elastography methods for noninvasive measurement of tissue mechanical properties have been under development for nearly three decades. Much of the technological development to date, for both Ultrasound (US)-based and Magnetic Resonance Imaging (MRI)-based strategies, has been grounded in assumptions of local homogeneity and isotropy. Striated skeletal and cardiac muscle, as well as brain white matter and soft tissue in some other organ regions, exhibit a fibrous microstructure which entails heterogeneity and anisotropic response; as one seeks to improve the accuracy and resolution in mechanical property assessment, heterogeneity and anisotropy need to be accounted for in order to optimize both the dynamic elastography experimental protocol and the interpretation of the measurements. Advances in elastography methodology at every step have been aided by the use of tissue-mimicking phantoms. The aim of the present study was to develop and characterize a heterogeneous composite phantom design with uniform controllable anisotropic properties meant to be comparable to the frequency-dependent anisotropic properties of skeletal muscle. MRE experiments and computational finite element (FE) studies were conducted on a novel 3D-printed composite phantom design. The displacement maps obtained from simulation and experiment show the same elliptical shaped wavefronts elongated in the plane where the structure presents higher shear modulus. The model exhibits a degree of anisotropy in line with literature data from skeletal muscle tissue MRE experiments. FE simulations of the MRE experiments provide insight into proper interpretation of experimental measurements, and help to quantify the importance of heterogeneity in the anisotropic material at different scales.

LanguageEnglish (US)
Pages199-208
Number of pages10
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume89
DOIs
StatePublished - Jan 1 2019

Fingerprint

3D printers
Homogenization method
Biomechanics
Viscoelasticity
Medical imaging
Magnetism
Pathology
Magnetic resonance
Magnetic resonance imaging
Muscle
Anisotropy
Tissue
Finite element method
Mechanical properties
Composite materials
Experiments
Wavefronts
Brain
Elastic moduli
Ultrasonics

Keywords

  • Anisotropy
  • Finite element
  • Homogenization
  • Magnetic resonance elastography
  • Skeletal muscle tissue
  • Viscoelasticity

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

Cite this

Anisotropic composite material phantom to improve skeletal muscle characterization using magnetic resonance elastography. / Guidetti, Martina; Lorgna, Gloria; Klatt, Dieter; Vena, Pasquale; Royston, Thomas J.

In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 89, 01.01.2019, p. 199-208.

Research output: Contribution to journalArticle

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