Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI

L. M. Jenkins, A. D. Kendall, M. T. Kassel, V. G. Patrón, J. R. Gowins, C. Dion, S. A. Shankman, S. L. Weisenbach, P. Maki, S. A. Langenecker

Research output: Research - peer-reviewArticle

Abstract

Background Sex differences in emotion processing may play a role in women's increased risk for Major Depressive Disorder (MDD). However, studies of sex differences in brain mechanisms involved in emotion processing in MDD (or interactions of sex and diagnosis) are sparse. Methods We conducted an event-related fMRI study examining the interactive and distinct effects of sex and MDD on neural activity during a facial emotion perception task. To minimize effects of current affective state and cumulative disease burden, we studied participants with remitted MDD (rMDD) who were early in the course of the illness. In total, 88 individuals aged 18–23 participated, including 48 with rMDD (32 female) and 40 healthy controls (HC; 25 female). Results fMRI revealed an interaction between sex and diagnosis for sad and neutral facial expressions in the superior frontal gyrus and left middle temporal gyrus. Results also revealed an interaction of sex with diagnosis in the amygdala. Limitations Data was from two sites, which might increase variability, but it also increases power to examine sex by diagnosis interactions. Conclusions This study demonstrates the importance of taking sex differences into account when examining potential trait (or scar) mechanisms that could be useful in identifying individuals at-risk for MDD as well as for evaluating potential therapeutic innovations.

LanguageEnglish (US)
Pages129-136
Number of pages8
JournalJournal of Affective Disorders
Volume225
DOIs
StatePublished - Jan 1 2018

Fingerprint

Major Depressive Disorder
Sex Characteristics
Emotions
Magnetic Resonance Imaging
Depression
Facial Expression
Temporal Lobe
Amygdala
Prefrontal Cortex
Cicatrix
Brain
Therapeutics
Power (Psychology)

Keywords

  • Facial emotion perception
  • FMRI
  • Major depression
  • Remitted
  • Sex differences
  • Superior frontal gyrus

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI. / Jenkins, L. M.; Kendall, A. D.; Kassel, M. T.; Patrón, V. G.; Gowins, J. R.; Dion, C.; Shankman, S. A.; Weisenbach, S. L.; Maki, P.; Langenecker, S. A.

In: Journal of Affective Disorders, Vol. 225, 01.01.2018, p. 129-136.

Research output: Research - peer-reviewArticle

Jenkins, LM, Kendall, AD, Kassel, MT, Patrón, VG, Gowins, JR, Dion, C, Shankman, SA, Weisenbach, SL, Maki, P & Langenecker, SA 2018, 'Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI' Journal of Affective Disorders, vol 225, pp. 129-136. DOI: 10.1016/j.jad.2017.08.027
Jenkins LM, Kendall AD, Kassel MT, Patrón VG, Gowins JR, Dion C et al. Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI. Journal of Affective Disorders. 2018 Jan 1;225:129-136. Available from, DOI: 10.1016/j.jad.2017.08.027
Jenkins, L. M. ; Kendall, A. D. ; Kassel, M. T. ; Patrón, V. G. ; Gowins, J. R. ; Dion, C. ; Shankman, S. A. ; Weisenbach, S. L. ; Maki, P. ; Langenecker, S. A./ Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI. In: Journal of Affective Disorders. 2018 ; Vol. 225. pp. 129-136
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