Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis

Rasha E. Shalaby, Saira Iram, Claudia E. Oropeza, Alan McLachlan

Research output: Contribution to journalArticle

Abstract

Transcriptional coactivators represent critical components of the transcriptional pre-initiation complex and are required for efficient gene activation. Members of the peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) family differentially regulate hepatitis b virus (HBV) biosynthesis. Whereas PGC1α has been shown to be a potent activator of HBV biosynthesis, PGC1β only very poorly activates HBV RNA and DNA synthesis in human hepatoma (HepG2) and embryonic kidney (HEK293T) cells. Furthermore, PGC1β inhibits PGC1α-mediated HBV biosynthesis. These observations suggest that a potential competition between human hepatoma (HepG2) and embryonic kidney (HEK293T) cells PGC1α and PGC1β for common transcription factor target(s) may regulate HBV transcription and replication in a context and signal transduction pathway dependent manner.

LanguageEnglish (US)
Pages214-221
Number of pages8
JournalVirology
Volume526
DOIs
StatePublished - Jan 2 2019

Fingerprint

Hepatitis Viruses
PPAR gamma
Hepatocellular Carcinoma
Kidney
Virus Replication
Transcriptional Activation
Signal Transduction
Transcription Factors
RNA
DNA

Keywords

  • Coactivator competition
  • Hepatitis b virus
  • Peroxisome proliferator-activated receptor γ coactivator
  • Transcription coactivator
  • Transcription regulation
  • Viral replication

ASJC Scopus subject areas

  • Virology

Cite this

Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis. / Shalaby, Rasha E.; Iram, Saira; Oropeza, Claudia E.; McLachlan, Alan.

In: Virology, Vol. 526, 02.01.2019, p. 214-221.

Research output: Contribution to journalArticle

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