Phytoconstituents from Vitex agnus-castus fruits

Shaonong Chen, John B. Friesen, Donna Webster, Dejan S. Nikolic, Richard B. Van Breemen, Zaijie Wang, Harry H S Fong, Norman R. Farnsworth, Guido F. Pauli

Research output: Contribution to journalArticle

  • 34 Citations

Abstract

A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.

LanguageEnglish
Pages528-533
Number of pages6
JournalFitoterapia
Volume82
Issue number4
DOIs
StatePublished - Jun 1 2011

Fingerprint

Vitex
Apigenin
Luteolin
Glycerides
Lignans
delta Opioid Receptor
Diterpenes
mu Opioid Receptor
Terpenes
Flavonoids
Fruit
Ligands
3-methylkaempferol
casticin
viteagnusin I

Keywords

  • Flavonoids
  • Labdane diterpene
  • Opioid activity
  • Viteagnusin I
  • Vitex agnus-castus

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Phytoconstituents from Vitex agnus-castus fruits. / Chen, Shaonong; Friesen, John B.; Webster, Donna; Nikolic, Dejan S.; Van Breemen, Richard B.; Wang, Zaijie; Fong, Harry H S; Farnsworth, Norman R.; Pauli, Guido F.

In: Fitoterapia, Vol. 82, No. 4, 01.06.2011, p. 528-533.

Research output: Contribution to journalArticle

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