Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen

G. B. Mahady, S. L. Pendland, G. Yun, Z. Z. Lu

Research output: Contribution to journalArticle

  • 144 Citations

Abstract

Background: Curcumin, a polyphenolic chemical constituent derived from turmeric (Curcuma longa), has been shown to prevent gastric and colon cancers in rodents. Many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen and is associated with the development of gastric and colon cancer. Materials and Methods. A methanol extract of the dried powdered turmeric rhizome and curcumin were tested against 19 strains of H. pylori including 5 cagA+ strains. Results: Both the methanol extract and curcumin inhibited the growth of all strains of H. pylori in vitro with a minimum inhibitory concentration range of 6.25-50 μg/ml. Conclusion: These data demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in vitro, and this may be one of the mechanisms by which curcumin exerts its chemopreventative effects.

LanguageEnglish
Pages4179-4181
Number of pages3
JournalAnticancer Research
Volume22
Issue number6 C
StatePublished - Nov 1 2002

Fingerprint

Curcuma
Curcumin
Helicobacter pylori
Carcinogens
Growth
Colonic Neoplasms
Stomach Neoplasms
Methanol
Rhizome
Microbial Sensitivity Tests
Rodentia

Keywords

  • Chemoprevention
  • Curcuma longa
  • Curcumin
  • Helicobacter pylori
  • Turmeric

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. / Mahady, G. B.; Pendland, S. L.; Yun, G.; Lu, Z. Z.

In: Anticancer Research, Vol. 22, No. 6 C, 01.11.2002, p. 4179-4181.

Research output: Contribution to journalArticle

@article{6bc400eb907d481d8161d9a5c8f72dda,
title = "Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen",
abstract = "Background: Curcumin, a polyphenolic chemical constituent derived from turmeric (Curcuma longa), has been shown to prevent gastric and colon cancers in rodents. Many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen and is associated with the development of gastric and colon cancer. Materials and Methods. A methanol extract of the dried powdered turmeric rhizome and curcumin were tested against 19 strains of H. pylori including 5 cagA+ strains. Results: Both the methanol extract and curcumin inhibited the growth of all strains of H. pylori in vitro with a minimum inhibitory concentration range of 6.25-50 μg/ml. Conclusion: These data demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in vitro, and this may be one of the mechanisms by which curcumin exerts its chemopreventative effects.",
keywords = "Chemoprevention, Curcuma longa, Curcumin, Helicobacter pylori, Turmeric",
author = "Mahady, {G. B.} and Pendland, {S. L.} and G. Yun and Lu, {Z. Z.}",
year = "2002",
month = "11",
day = "1",
language = "English",
volume = "22",
pages = "4179--4181",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "6 C",

}

TY - JOUR

T1 - Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen

AU - Mahady,G. B.

AU - Pendland,S. L.

AU - Yun,G.

AU - Lu,Z. Z.

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Background: Curcumin, a polyphenolic chemical constituent derived from turmeric (Curcuma longa), has been shown to prevent gastric and colon cancers in rodents. Many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen and is associated with the development of gastric and colon cancer. Materials and Methods. A methanol extract of the dried powdered turmeric rhizome and curcumin were tested against 19 strains of H. pylori including 5 cagA+ strains. Results: Both the methanol extract and curcumin inhibited the growth of all strains of H. pylori in vitro with a minimum inhibitory concentration range of 6.25-50 μg/ml. Conclusion: These data demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in vitro, and this may be one of the mechanisms by which curcumin exerts its chemopreventative effects.

AB - Background: Curcumin, a polyphenolic chemical constituent derived from turmeric (Curcuma longa), has been shown to prevent gastric and colon cancers in rodents. Many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen and is associated with the development of gastric and colon cancer. Materials and Methods. A methanol extract of the dried powdered turmeric rhizome and curcumin were tested against 19 strains of H. pylori including 5 cagA+ strains. Results: Both the methanol extract and curcumin inhibited the growth of all strains of H. pylori in vitro with a minimum inhibitory concentration range of 6.25-50 μg/ml. Conclusion: These data demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in vitro, and this may be one of the mechanisms by which curcumin exerts its chemopreventative effects.

KW - Chemoprevention

KW - Curcuma longa

KW - Curcumin

KW - Helicobacter pylori

KW - Turmeric

UR - http://www.scopus.com/inward/record.url?scp=0036875379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036875379&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 4179

EP - 4181

JO - Anticancer Research

T2 - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 6 C

ER -